PRENUT
PREloads of mixed NUTs for diabetes prevention
An international clinical trial evaluating mixed nuts as a prandial strategy for type 2 diabetes prevention.
PRENUT is an international, multi-centre randomized clinical trial designed to assess whether consuming mixed nuts before meals can help prevent type 2 diabetes in high-risk individuals.
About the PRENUT trial
The PRENUT trial will evaluate the effect of consuming 20 g of mixed nuts 30 minutes before each main meal, three times per day, in addition to standard care, compared with standard care alone.
The study will include adults with prediabetes and other major risk factors for type 2 diabetes, including obesity, family history of type 2 diabetes and a high diabetes risk score.
The main goal of PRENUT is to generate high-quality clinical evidence on the role of mixed nuts as a practical nutritional strategy for type 2 diabetes prevention.
Why PRENUT?
Type 2 diabetes is one of the major global public health challenges. Although lifestyle and dietary interventions are central to diabetes prevention, there is still a need for practical, evidence-based strategies that can be implemented across different populations and healthcare settings.
Previous research suggests that nuts may help reduce postprandial glycemia and improve glycemic control and cardiometabolic risk factors. The PRENUT trials aims to determine whether consuming nuts before each main meal can be a nutritional strategy to prevent type 2 diabetes.
Study at a glance
Study type
Interventional study
Design
Multi-centre, randomized, open-label, parallel-group, two-arm superiority trial
Project duration
5 years
Intervention period
3 years / 156 weeks
Participants
752 high-risk individuals with prediabetes
Intervention
20 g mixed nuts before each main meal, three times daily
Comparator
Standard care alone
Primary outcome
Time to type 2 diabetes event
Centers
Canada, United States, Spain and India
International participating centres
GLOBAL COLLABORATION
GLOBAL COLLABORATION
A collaborative international project
PRENUT brings together leading clinical nutrition, diabetes and public health research teams from North America, Europe and Asia. The project is designed to provide robust evidence that may contribute to future clinical practice, public health policies, nutrition guidance and implementation strategies for diabetes prevention.
Clinical practice
Findings with potential relevance for different populations and healthcare settings.
Public health policies
Findings with potential relevance for different populations and healthcare settings.
Nutrition and implementation
Practical insights that may contribute to nutrition guidance and prevention strategies.
Website purpose
This website will serve as the central communication platform for the PRENUT trial. It will provide general information about the project, updates on study progress, and private access areas for the research/medical team and study participants.